Immunological factors in diseases // Drug Repurposing

Immunological factors in diseases

coronary artery diseaseCoronary artery disease (CAD) is one of the most common causes of death in the United States. It can be a single common killer of both men and women. The true frequency of atherosclerosis is difficult to determine because it is predominantly a symptomatic condition which begins early in childhood with the development of fatty streaks. CAD occurs when the arteries of the heart harden and become narrowed. This is due to the buildup of lipids, cholesterol and other substances called a plaque. This buildup causes decrease in blood flow to the heart resulting in decreased distribution of oxygen and other nutrients to the heart muscle. At first, the heart will try to compensate. However, as the plaques continue to build this may cause signs and symptoms.

Risk Factors of CAD

Coronary atherosclerosis is thought to begin with damage or injury of the blood vessels. The damage may be influenced by a number of factors as follow:

There are a number of physiologic changes when the person grows old. Physiologic changes in the arteries occur such as stiffening and thickening that predisposes a person in having CAD.

coronary artery diseaseMen are generally at greater risk of coronary artery disease. However, at the age of 70 years old, the risk becomes equal to both sexes. Women who have other conditions such as gestational diabetes, preeclampsia, third trimester bleeding, preterm birth and birth of an infant small for gestational age increases the risk of having CAD.

A family history of heart disease predisposes a person of having coronary artery disease. There is a significant increase with if the first degree relatives of an individual who develops CAD at age 55-65 years old.

Vasoconstriction occurs during smoking and carbon monoxide can damage the inner lining of the blood vessels which poses higher risk of developing CAD. The incidence risk of heart attack in women who smoke 20 cigarettes per day is six times higher than that for non-smoker females. The incidence of the men who smoke is triple than that of non-smokers.

High levels of cholesterol in the blood increase the risk of plaque formation. High cholesterol levels are caused by increased low density lipoprotein (bad cholesterol) and relative lesser high density lipoprotein (good cholesterol).

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Health concerns

by veganpiratelady

About five months back I reckon I posted about some health concerns I was having. They seemed specifically pre-menstrual related. The issues, however, have persisted. It seems that the issues become worse around my cycle, but that they persist for the whole month. I have had what more or less feels like an ongoing case of the flu since about the New Year.
I have had three blood tests done and reviewed by two different doctors: an MD and an ND. The only abnormality was that on one of the blood test occasions I was a bit low on Magnesium, for which I received a shot

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