Why is drug resistance a problem? // Drug Repurposing

Why is drug resistance a problem?

cows in a fieldA landmark report from the US Centers for Disease Control and Prevention (CDC) gives the first snapshot of the toll and threat antibiotic-resistance poses to US health. The report ranks each threat and proposes four core actions to tackle the growing problem.

Antibiotic-resistance occurs when an infection does not respond to the drug developed to treat it because the germs have since changed in ways that make them immune to it.

As well as taking a considerable toll on health and life, antibiotic resistance is a huge economic burden for a health system that is already strained.

Studies suggest antibiotic resistance is responsible for some $20 billion direct health care costs and another $35 billion a year in lost productivity.

Community prevalence of drug-resistant bacteria

Once rare outside of hospitals, antibiotic-resistant infections are now increasingly arising in the community.

CDC Director Tom Frieden said in a news conference on Monday:

"Antibiotic resistance is rising for many different pathogens that are threats to health. If we don't act now, our medicine cabinet will be empty and we won't have the antibiotics we need to save lives."

Steve Solomon, director of the Office of Antimicrobial Resistance at the CDC adds:

"These drugs are a precious, limited resource - the more we use antibiotics today, the less likely we are to have effective antibiotics tomorrow."

The public health agency says the single biggest cause of antibiotic resistance is use of antibiotics, and up to half of all antibiotics prescribed for patients are either unnecessary or prescribed inappropriately.


Overuse of antibiotics in both humans and livestock can allow bacteria to evolve by developing resistance, which will have serious impacts on patients who acquire infections.

Another heavy user of antibiotics is farming, where animals are given antibiotics to prevent, control and treat disease, and also to promote growth. The CDC says it is just as important to use antibiotics judiciously here as with humans.

"Every time antibiotics are used in any setting, bacteria evolve by developing resistance. This process can happen with alarming speed, " says Solomon.

Loss of effective antibiotics will have a serious impact on patients with other diseases who then acquire infections. Also, people who undergo hip replacements, receive organ transplants, have cancer therapy, and other treatments, all depend on antibiotics to help them deal with any infections that might arise.

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Using Drugs w/ dangerous side effects 4 baldness

by sweet_clarity

Is medically irrisponsible
If rampant imflammation was putting this guy at risk for other health problems, than perhaps this course of treatment was medically wise.
Otherwise, drugs such as this one lower resistance to infection and leave people vulnerable to more serious diseases.
It's one thing to accept and monitor this risk because rheumatoid arthritis is chewing up tissue, putting people in continuous pain, preventing them from leading fulfilling lives.
Giving someone a drug like this for no other reason than being bald makes them socially uncomfortable

Trinity find may help defeat cancer drug resistance  — Irish Examiner
Irish researchers have discovered a molecule that could improve targeted treatments for breast cancer and a number of other cancers.