What Causes drug Resistance? // Drug Repurposing

What Causes drug Resistance?

featured imageLast fall I flew halfway across the country to go grocery shopping with Everly Macario. We set out from her second-story apartment in Hyde Park near the University of Chicago and walked to the supermarket to buy a couple of rib steaks that Macario planned to serve to her husband and two children, ages 7 and 13. Macario, who is 46, holds a doctorate in public health from Harvard University and has spent decades as a consultant, working to prevent deaths from chronic conditions such as cancer and cardiac disease.

Yet she believes that what she buys—or more accurately, refuses to buy—in the supermarket is the most important action she takes, not only for her family’s health but for the health of every person in this country. “I am determined that no product from an animal that has been fed antibiotics will ever enter my home, ” she said as we walked along the meat counter peering at beef, poultry and pork. “I look for labels that read ‘certified organic, ’ ‘no antibiotics’ or ‘raised without antibiotics.’”

It’s not the antibiotics themselves that are troubling: animals pass the drugs through their systems long before they are slaughtered and animal products are tested for traces of antibiotics. What really worries Macario is the increasing wave of antibiotic-resistant bacteria that might be traveling on her food.

Macario has reason to be vigilant. Her 18-month-old son, Simon, died in 2004 from an infection known as methicillin-resistant Staphylococcus aureus (or MRSA, pronounced “mersa”). Simon was a husky, happy toddler. On his first birthday, Macario marveled to her husband that the baby had never been sick.Supermom and Daughter Then one morning the boy awoke with, in Macario’s words, a “blood-curdling shriek.” Rushed to the hospital, Simon was put on a heart-lung machine. “The doctors administered every available antibiotic, ” she said. “It didn’t work. The bacteria were resistant to all of the medication.” In less than 24 hours he was dead. “The bacteria released toxins that destroyed his vital organs, ” Macario said.

You might also like

Drug-Resistant Tuberculosis: Alarming Number Of Cases
Drug-Resistant Tuberculosis: Alarming Number Of Cases ...
The Threat of Drug-Resistant Tuberculosis
The Threat of Drug-Resistant Tuberculosis

Would help to know what the pill IS....

by --

What is the best oral treatment for yeast vaginitis?
Oral treatment of yeast can use nystatin, amphotericin B or fluconazole(Diflucan®), although fluconazole is used most frequently for yeast vaginitis. Treating yeast vaginitis by oral medicine, however is not the first choice, recommended treatment. Topical vaginal treatment with butaconazole (Femstat® Nystatin ®) is the first choice treatment rather than oral fluconazole (Diflucan®) because it is non-prescription and very effective. Fluconazole is effective but non candida albicans species are becoming more resistant to it an requiring higher doses to eradicate the yeast (4, 5)


by sfuser

I read this in The New Republic a few weeks back. I've found myself thinking about it frequently, so naturally I decided to impose my preoccupation on the board.
The article talks about a branch of psychiatry that tries to focus on what causes happiness, rather than what causes dysfunction. I felt that the article not only discussed some practical trends in psych, but also provided readers with some good ways to achieve greater happiness. It's moderately lengthy (I'd guess 4,000 words).
Psychology discovers happiness

Trinity find may help defeat cancer drug resistance  — Irish Examiner
Irish researchers have discovered a molecule that could improve targeted treatments for breast cancer and a number of other cancers.