Resistance to drugs // Drug Repurposing

Resistance to drugs

Dr Maceij BoniDo we have any leverage against drug-resistant organisms? explains the biological fitness cost of drug resistance and the worrisome scenarios that could develop if we lose this small advantage in our fight against drug-resistant pathogens. Dr Boni is a Wellcome Trust–Royal Society Sir Henry Dale Fellow leading a research programme on the epidemiology and evolution of influenza in the tropics. Parts of his doctoral and postdoctoral work focused on developing public health strategies aimed at rolling back drug resistance.

Can we eliminate drug resistance?

N0029399 Testing bacteria for antibiotic sensitivityIn some areas of global health we have made great strides over the past decade. Although much remains to be done, great progress has been made in the fields of malaria, HIV, the neglected tropical diseases, tuberculosis and many other infections. Maternal and child health have been improving, and funding for global health programmes has increased significantly. But the rise of drug resistance puts many of these advances at grave risk.

Drug resistance became a major public health problem in the later decades of the 20th century, as the world’s most serious pathogens began to repeatedly demonstrate the ability to elude our best treatments. In the 21st century this international threat to public health cannot be ignored.

Under extreme pressure from antibiotics, antivirals or other drugs, the majority of the world’s pathogens have – sometimes quickly, sometimes slowly – evolved resistance to the drugs we use to combat them. For the pathogens, this benefit of drug resistance has typically come at a cost; although resistant pathogens have a biological advantage in the presence of an antibiotic, they are less fit than sensitive pathogens when the antibiotic pressure is removed and tend to die out. Thus, it appeared that natural selection had given us a foothold on this problem by making drug-resistant organisms more flawed than their drug-sensitive counterparts. However, recent results from a team of Wellcome Trust investigators and a team of NIH-funded investigators have shown that some pathogens are now able to develop drug resistance without that biological cost.

“This would be a nightmare scenario”

“This would be a nightmare scenario, ” says Dr Jeremy Farrar, Director of the Wellcome Trust, “that resistant pathogens might be selected when exposed to antibiotics, but would expand in numbers even if the antibiotic pressure is removed”.

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Sorry no AGW or HICC link as claimed

by JimmyCap

The linkage she made was the Climate Change was causing Denge Fever and Malaria increases. It is not.
It is linked to Clear Cutting
And the usual Suspects. Read the report by WHO and UNICEF that attributes the high Malaria death rates in Africa to inadequate medical care, failure to use insecticide treated nets and increased resistance to drugs.
again, you Warmista are wrong

The you need to see this:

by Godly_Warrior

A simple testimony. < Godly_Warrior > 06/22 16:29:28
I heard the Word. I believed it. I received it.
Now, I am a new creation in Christ. (2 Cor. 5:17)
I gave up my habitual sins revolving around sex, drugs, and rock-and-roll and now I live to please Him. I take the charge to spread the news to heart.
Thee are many parts to the body, but:
1 Cor 12:16 17 If the whole body were an eye, how would you hear? Or if your whole body were an ear, how would you smell anything?
My calling is to spread the news. That will be met with resistance by the forces of evil

Evolution and how it affects you today

by Marcus144

Excerpted from NY Times "...Acinetobacter baumannii. The germ is one of a category of bacteria that by some estimates are already killing tens of thousands of hospital patients each year. While the organisms do not receive as much attention as the one known as MRSA -- for methicillin-resistant Staphylococcus aureus -- some infectious-disease specialists say they could emerge as a bigger threat.
That is because there are several drugs, including some approved in the last few years, that can treat MRSA. But for a combination of business reasons and scientific challenges, the pharmaceuticals industry is pursuing very few drugs for Acinetobacter and other organisms of its type, known as Gram-negative bacteria

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Trinity find may help defeat cancer drug resistance  — Irish Examiner
Irish researchers have discovered a molecule that could improve targeted treatments for breast cancer and a number of other cancers.

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