Drug-resistant TB // Drug Repurposing

Drug-resistant TB

Home > blog > Drug-Resistant Tuberculosis: What It Is, Why It’s Here, And How We Should Respond

Tuberculosis (TB) evokes two images in my mind; overcrowded, TB-infected prisons expounded upon by Paul Farmer and the Hollywood film success, Moulin Rouge. But since the recent outbreak of the so-called totally-drug-resistant tuberculosis (TDR-TB) in India, TB has a new face. In the evolutionary arms race between human and bacterium, Mycobacterium tuberculosis, the causative agent of tuberculosis, appears to be pulling ahead.

M. tuberculosis is a rod-shaped bacterium that is transmitted via tiny water droplets exchanged between human hosts. On the rare occasion that the bacteria reach the small air sacs, alveoli, of the human lung, infection occurs. In the majority of cases, the body is capable of containing the TB infection. The bacteria can remain latent, or inactive, for many years inside the individual before it manifests symptoms of active disease. When containment fails, active and symptomatic TB disease can develop. The bacteria infect immune cells, which prevents our immune system’s frontline defenses from containing the bacteria and protecting us effectively. In these cases, we bring out the big guns; specialized immune cells that specifically recognize and target the bacteria. It is our own immune response to infection that results in the majority of symptoms—bloody sputum, chest pains, fever, and weight loss—that are the hallmarks of TB infection.

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An illegal alien with drug-resistant TB

by refuses-treatment

Source: The Daily Courier
An illegal immigrant from Mexico with tuberculosis cost the public thousands of dollars in unreimbursed health care this past year after Yavapai County Community Health Services workers spent two months overseeing the patient's TB care before the patient died of other medical complications.
County officials estimate that it cost somewhere between $5,305 to $8,564 to care for the patient and to test the people who came in contact with the person. If any of those people eventually come down with TB, the cost to the county will increase.
County officials said because the person - whom they would not identify by name or gender - eventually refused to take the numerous medications required of TB patients, they thought about sending the person to an isolation unit in a Phoenix jail for supervision. The Yavap…

=== TB is here

by viscute

===U.S. immigrants pose TB threat
From coast to coast, more cases found
raising fears of new drug-resistant strain.
Posted: October 22, 2006
1:00 a.m. Eastern
© 2006 WorldNetDaily. com
WASHINGTON – The worst forms of a drug-resistant killer tuberculosis bug, rapidly spreading throughout the world, have been gaining ground in the United States along with record legal and illegal immigration levels, alarming public-health officials over a disease once thought vanquished.
Although the number of confirmed drug-resistant TB cases in the U.S. is relatively small – still measured in the dozens – health officials say visitors from other countries are bringing in the deadliest mutations

TB Silent Killer
TV Series Episode Video on Demand ()

Patients to be screened for extensively drug-resistant TB at CMCH from July 1  — The Hindu
All the multi drug-resistant tuberculosis (MDR TB) patients coming for treatment at the Coimbatore Medical College Hospital (CMCH) will be diagnosed immediately for extensively drug-resistant tuberculosis (XDR-TB) from July 1.

BiblioGov House Hearing, 110th Congress: The Global Threat of Drug-Resistant Tb: A Call to Action for World Tb Day
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