Drug resistant strains // Drug Repurposing

Drug resistant strains

via The Global FundThis week, the World Health Organization (WHO) published its annual Global Tuberculosis Report. I have been following tuberculosis (TB) quite closely for the past 3 years, and it is a disease that increasingly worries me. This year’s report findings should be worrying to everyone.

Photo credit: The Global Fund

TB is an air-borne infectious disease that gained prominence in the past decade “thanks” to the HIV/AIDS crisis. People who are HIV-positive are over 50 times more likely to be infected by TB. But it also affects HIV-negative people – as well as fully healthy people. There is currently no effective prevention for TB, and without treatment, it’s a lethal disease.

via The Global FundThanks (and this time without quotations!) to organizations like the Global Fund to Fight AIDS, Tuberculosis and Malaria, TB detection and treatment rates have been increasing. And subsequently, death rates have been falling globally – albeit very slowly. In 2012, 1.3 million people died from TB.

What is hugely worrying is the rise of drug-resistant strains of TB, which, as implied in the name, are forms of TB that are not treatable by conventional drugs. I recently attended a workshop on drug-resistant TB, where MDR-TB (multi-drug resistant TB), XDR-TB (extremely drug resistant TB), and even TDR-TB (totally drug resistant TB) were discussed.

A representative from Doctors Without Borders (MSF) underlined the key problem and cause in the rise of drug resistance: the lack of new TB drugs. The last TB drug available to most people was developed in the 1950s. Imagine if we were still using the same cars and televisions our grandparents used.

WHO estimates that 450, 000 people fell ill with MDR-TB in 2012 alone. Many of those people did not receive treatment, and even among those who did, just under half (48 percent) were cured after 2 years.

What provides hope is that there are some potentially effective new drugs for treatment in the pipeline. Vaccines to prevent TB are also under development. There’s a brilliant short film series about TB and vaccines available online for those who’d like to learn more. As the films show, much more needs to be invested into research and development.

The Global Fund to Fight AIDS, Tuberculosis and Malaria is gathering funds from donors in just over a month, on December 3rd. Please support our petition to ensure that we can continue to effectively fight these three killer diseases.

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Because some things are not profitable

by ear_rational

The last pharma company that was doing research on new antibiotics to fight the drug resistant strains just abandoned their research because it is not profitable like drugs for heartburn or cholesterol...things that have to be taken long term.....
The pharmas concentrate their resources on the most profitable areas.....not on what is best for health....

And one more thing

by UWSItalian

He says he's neg, but you don't know that. And I don't think that for *you* the risk of getting a different strain of the virus is worth it.
The NYC Health Dept might have blown the whistle inappropriately last month, but I think it's bound to happen that drug resistant strains (which are already out there) will start becoming prevalent.

Oh, now I get it, this is the fundie acceptance

by johnstuartmills0

Of their invented "micro-evolution" of organisms like drug resistant strains of malaria.
They used to deny all evolution but it became untenable when we had the DNA sequences showing the changes in genes (the MUTATIONS) in the resistant organisms.
Now they pretend that they had this idea of 2 types of evolution all along.
They are such lying morons.

Novel HIV medications target emerging drug-resistant strains. (New Focus on Rescue Regimens).(Brief Article): An article from: Family Practice News
Book (International Medical News Group)

Research may yield new ways to treat antibiotic-resistant TB  — Phys.Org
The findings, reported in the Journal of Biological Chemistry, indicate that a new compound, 24-desmethylrifampicin, has much better antibacterial activity than rifampicin against multi-drug-resistant strains of the bacteria that cause tuberculosis ..

More than half of HIV-infected people carry drug-resistant strains. (First National Survey of HIV Resistance).: An article from: Internal Medicine News
Book (International Medical News Group)
Novel HIV medications target resistant strains. (Antiretroviral Drugs).(Brief Article): An article from: Internal Medicine News
Book (International Medical News Group)
Comparative Drug Responses of Sensitive and Resistant Strains of Malaria Parasites Using in Vitro Bioassays and Animal Models for Blood and Tissue Schizontocidal Activity and Mechanism of Reversal of Resistance &Toxicity of Antimalarials
Book (PN)
Comparative Drug Response of Sensitive and Resistant Strains of Malarial Parasites Using in vitro Bioassays and Animal Models
Book (PN)