Drug resistant e coli treatment // Drug Repurposing

Drug resistant e coli treatment

utiThanks to antibiotics, we tend to think of urinary tract infections as no big deal. Pop some cipro, and you’re done. A good thing, too—if the E. coli that usually cause UTIs crawl up the urinary tract, they can cause kidney failure and fatal blood poisoning.

But antibiotics may not be saving us from UTIs for very much longer. Scientists tracking UTIs from 2000 to 2010 found a dramatic uptick in cases caused by E. coli that do not respond to the drugs that are our first line of defense. In examining more than 12 million urine analyses from that period, they found that cases caused by E. coli resistant to ciprofloxacin grew five-fold, from 3% to 17.1% of cases. And E. coli resistant to the drug trimethoprim-sulfame-thoxazole jumped from 17.9% to 24.2%. These are two of the most commonly prescribed antibiotics used to treat UTIs. When they are not effective, doctors must turn to more toxic drugs, and the more those drugs are used, the less effective they in turn become.uti When those drugs stop working, doctors will be left with a drastically reduced toolkit with which to fight infection.

Some of this growing resistance in E. coli and other bacteria is due to the fact that antibiotics are being overprescribed, handed out to patients who have no bacterial infections. There is also evidence that the genes that give bacteria resistance to drugs are being spread in livestock farming operations, where antibiotics are a common ingredient in animal feed. Ciprofloxacin is one of those antibiotics, and researchers have found that E. coli resistant to it are thriving in poultry farms. Very closely related strains of drug-resistant E. coli have been found in people, suggesting that the bugs spread from the birds to humans.

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More GOOD NEWS:The world is being driven towards

by ZoeysKid2

The world is being driven towards the "unthinkable scenario of untreatable infections", experts are warning, because of the growth of superbugs resistant to all antibiotics and the dwindling interest in developing new drugs to combat them.
Reports are increasing across Europe of patients with infections that are nearly impossible to treat. The European Centre for Disease Control and Prevention (ECDC) said yesterday that in some countries up to 50 per cent of cases of blood poisoning caused by one bug – K. pneumoniae, a common cause of urinary and respiratory conditions – were resistant to carbapenems, the most powerful class of antibiotics

Book (PN)

Linda Cannon: Book covers gripping disease studies  — Joplin Globe
Other chapters cover the discovery of hantavirus out west, an ice cream linked outbreak of salmonella, the Legionnaire's disease outbreak and a refugee story that shows just how easily a widespread outbreak of any number of drug-resistant diseases ..