Drug resistance database
Tuberculosis is a global health threat
Tuberculosis (TB) remains the leading cause of death in the world from a preventable and curable infectious disease. The emergence and spread of anti-TB drug resistance has developed into a serious threat to the global TB control plans. Standard methods to diagnose drug resistant TB rely on culture and phenotypic drug susceptibility testing (DST). Since M. tuberculosis grows slowly, routine DST can take weeks to months, delays during which patients receive suboptimal therapy that may lead to development of additional resistance and further spread of drug resistant TB.
Novel diagnostic tools are needed
New tools for rapid diagnosis of drug resistant TB are urgently needed. Sequence based diagnostic methods are being developed that detect specific mutations associated with drug resistance; these tools have the advantage of being rapid, high-throughput, and easily compared between laboratories. The development of such diagnostic tools relies on information about mutations that lead to drug resistance and evaluations of the relative frequency of these specific mutations.
Mutations confer drug resistance
In response to this urgent need to improve diagnostics of resistant TB, we have compiled a comprehensive list of the genetic polymorphisms associated with first and second line drug resistance in clinical isolates throughout the world. We have reviewed the most common mutations found for the major groups of anti-tuberculosis drugs, establishing a database that we hope will enable the development of sequence based tools for diagnosis and surveillance of drug resistance in tuberculosis.
You might also like
RE: War on Terrorism by Jesus__H__Christ
To fight the
War on Terrorism
Kerry will start the T.A.R.E.
Terror Abuse Resistance Education
Keep kids off terror!
Like the drug thing they threw away one-trillion dollars on.
The War on Terror will cost one-thousand trillion dollars!
Woo-hoo! Happy days are here for Halliburton!
Racism and the Prison Industrial Complexby forthehopeful
Masked Racism: Reflections on
the Prison Industrial Complex
By Angela Y. Davis
Imprisonment has become the response of first resort to far too many of the social problems that burden people who are ensconced in poverty. These problems often are veiled by being conveniently grouped together under the category 'crime' and by the automatic attribution of criminal behavior to people of color. Homelessness, unemployment, drug addiction, mental illness, and illiteracy are only a few of the problems that disappear from public view when the human beings contending with them are relegated to cages
Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods
eBooks (Academic Press)
Awards presented at Hoyle School — spectator.southcoasttoday
He noted that Lt. Cabral served as the Drug Awareness Resistance Education (DARE) officer for three years without being paid after the town went through a difficult financial time.