Cancer drug resistance an evolving paradigm // Drug Repurposing

Cancer drug resistance an evolving paradigm

For men in the United States, prostate cancer is the most commonly diagnosed solid tumor malignancy. It is one of the highest cancer-specific causes of death, second only to lung cancer.1

At the time of diagnosis with prostate cancer, most men have early-stage, asymptomatic disease. Prostate cancer is typically identified through prostate-specific antigen (PSA) testing and a digital rectal examination, and confirmed with a needle biopsy. When biopsy results are positive, the affected tissue is assessed microscopically and a Gleason score is calculated. In conjunction with other disease features and diagnostic test results, this score helps urologists determine the disease stage and prognosis, and facilitates the selection of initial therapy.2 Active surveillance, external radiation therapy, brachytherapy, radical prostatectomy, and androgen deprivation therapy (ADT) are relevant treatment options for men in the early stages of prostate cancer. Treatment selection is influenced by the risk of disease recurrence, the patient’s life expectancy, and quality-of-life considerations.3

Even with treatment, prostate cancer often progresses. Among patients with biochemical recurrence of localized disease, more than one third (33%) of men who are treated with surgery or radiation are not cured. In men who are treated with ADT, nearly all will go on to develop castration-resistant prostate cancer (CRPC). CRPC is characterized by a rising PSA level despite a castrate testosterone level of

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Why are bacteria becoming resistant to antibiotics?
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