Antimicrobial drug resistance // Drug Repurposing

Antimicrobial drug resistance

Antimicrobial resistance (AMR) threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. A post-antibiotic era – in which common infections and minor injuries can kill – far from being an apocalyptic fantasy, is instead a very real possibility for the 21st Century. This WHO report, produced in collaboration with Member States and other partners, provides for the first time, as accurate a picture as is presently possible of the magnitude of AMR and the current state of surveillance globally.

The dangers of hubris on human health

8 August 2013 - The video "The dangers of hubris on human health - the rapid emergence of antimicrobial drug resistance" is about the global heath security emergency that is arising due to emergence of microorganisms that are no longer treatable because of their resistance to virtually all available antimicrobial treatment options. The interview of Dr Keiji Fukuda, WHO Assistant Director-General, was produced in relation to the release of the World Economic Forum’s Global Risks Report 2013, in which one of the case studies addressed antimicrobial resistance as a global risk.

About antimicrobial resistance

WHO /Tom Pietrasik

Antimicrobial resistance (AMR) is the ability of microorganisms that cause disease to withstand attack by antimicrobial medicines. From drugs used to treat common bacterial infections, to the complex combinations now fighting HIV infection, resistance is increasingly being detected and is spreading rapidly. In some parts of the world, once powerful medicines against malaria and tuberculosis have now become virtually useless. AMR is rapidly becoming a major public health risk and is threatening to undo decades of advances in our ability to treat disease. It is challenging our whole understanding of how we control communicable disease.

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Interesting egg info

by -

Information obtained by the Canadian Integrated Program for Antimicrobial Resistance (CIPARS) “strongly indicates that cephalosporin resistance in humans is moving in lockstep with use of the drug in poultry production.”
According to the Canadian Medical Association Journal, the unapproved antibiotic ceftiofur is routinely injected into eggs in Quebec and Ontario to discourage infection of hatchlings. Although the data are contested by the industry, antibiotic resistance in humans appears to be directly related to the antibiotic's use in eggs

Pub Med Link Re: E.Coli In Semen

by LaChicka

Virulence characteristics of male genital tract Escherichia coli isolated from semen of suspected infertile men.
Bartoov B, Ozbonfil D, Maayan MC, Ohad E, Nitzan Y.
Department of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
The role of Escherichia coli isolates from the semen in the etiology of male infertility, was investigated in this study. Several possible virulence factors of E. coli, such as possession of O antigens or certain K antigens (K1, K5), the type of fimbriae, resistance to antimicrobial drugs and adherence studies to various mammalian sperm cells were examined

Fuckem we want needs guns much longer

by afavorate

Dame Sally Davies, chief medical officer for England, said action is urgently needed to fight antibiotic and antimicrobial resistance and that new drugs must be developed to treat new mutating infections.
She warned that if nothing is done to reverse the situation Britain would face an apocalyptic scenario with “a health system not dissimilar from the 19th century.”
Two months ago Dame Davies warned British legislators that antibiotic resistance should be added to the UK’s national risk register. The register was set up in 2008 to advise the public and businesses on national emergencies that the UK could face in the next five years

Well, I am not a vaccinologist but

by PhageDude

This form of antibody-mediated immunity does seem an awful lot like opsonization. One just has to find a way to tune the immune response to increase the production of IgG, which I know is a vital component of vaccine development anyway, likly by the use of adjuvants.
I am *certain* that in the near future we will see data showing a specific isotype of IgG having the best affinity for TRIM21 and/or other similar cytotsolic receptors. Adjuvants that tune isotype switching are being worked out.
There also could be antimicrobial drug development that would not place pressure on the microbe to escape as readily; such as a drug that increases production or activity of TRIM21

Stuff you may know; stuff you may not know.

by Ellen_Back

Worried about the widespread use of antibiotics used in the raising of steer, pigs and poultry, and fearing the rise of antibiotic-resistant illness, the U.S. Food and Drug Administration began the process of withdrawing its approval for the non-medical use of penicillin and tetracyclines (scribd, posted by Wired magazine's Maryn McKenna in conjunction with one of her posts on this issue).
That was in 1977. The FDA stopped pursuing the process, and antibiotics have continued to be given in feed. But a recent court order may allow the FDA to oversee a major change to the system.
In late March of 2012, Judge Theodore H

Academic Press Antimicrobial Drug Resistance
Book (Academic Press)

We Need Global Response To Antibiotic Resistance Crisis  — SpaceCoastDaily.com
With antimicrobial drug resistance occuring everywhere in the world and not limited to industrialized nations, Dr. Dhople calls the worldwide medical community to action to more aggressively address this crisis. —Dr.

Humana Press Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, Volume 2 (Infectious Disease)
Book (Humana Press)
Humana Press Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, Volume 1 (Infectious Disease)
Book (Humana Press)
LAP LAMBERT Academic Publishing Antimicrobial drug resistance in Lower respiratory tract infection: A growing menace
Book (LAP LAMBERT Academic Publishing)
Progressive Management 21st Century Ultimate Medical Guide to Antibiotics and Antimicrobial Drug Resistance - Authoritative, Practical Clinical Information for Physicians and Patients (Two CD-ROM Set)
Book (Progressive Management)