Macrocycles in new drug Discovery // Drug Repurposing

Macrocycles in new drug Discovery

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This article has been cited by 6 ACS Journal articles (5 most recent appear below).

Ted W. Johnson, Paul F. Richardson, Simon Bailey, Alexei Brooun, Benjamin J. Burke, Michael R. Collins, J. Jean Cui, Judith G. Deal, Ya-Li Deng, Dac Dinh, Lars D. Engstrom, Mingying He, Jacqui Hoffman, Robert L. Hoffman, Qinhua Huang, Robert S. Kania, John C. Kath, Hieu Lam, Justine L. Lam, Phuong T. Le, Laura Lingardo, Wei Liu, Michele McTigue, Cynthia L. Palmer, Neal W. Sach, Tod Smeal, Graham L. Smith, Albert E. Stewart, Sergei Timofeevski, Huichun Zhu, Jinjiang Zhu, Helen Y. Zou, and Martin P. Edwards

Journal of Medicinal Chemistry2014 57 (11), 4720-4744

  • Discovery of (10)-7-Amino-12-fluoro-2, 10, 16-trimethyl-15-oxo-10, 15, 16, 17-tetrahydro-2H-8, 4-(metheno)pyrazolo[4, 3-][2, 5, 11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations

    Cover ImageTed W. Johnson, Paul F. Richardson, Simon Bailey, Alexei Brooun, Benjamin J. Burke, Michael R. Collins, J. Jean Cui, Judith G. Deal, Ya-Li Deng, Dac Dinh, Lars D. Engstrom, Mingying He, Jacqui Hoffman, Robert L. Hoffman, Qinhua Huang, Robert S. Kania, John C. Kath, Hieu Lam, Justine L. Lam, Phuong T. Le, Laura Lingardo, Wei Liu, Michele McTigue, Cynthia L. Palmer, Neal W. Sach, Tod Smeal, Graham L. Smith, Albert E. Stewart, Sergei Timofeevski, Huichun Zhu, Jinjiang Zhu, Helen Y. Zou, and Martin P. Edwards

    Although crizotinib demonstrates robust efficacy in anaplastic lymphoma kinase (ALK)-positive non-small-cell lung carcinoma patients, progression during treatment eventually develops. Resistant patient samples revealed a variety of point mutations in the ...

Elizabeth A. Ilardi, Edon Vitaku, and Jon T. Njardarson

Cover ImageJournal of Medicinal Chemistry2014 57 (7), 2832-2842

  • Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery

    Cover ImageJournal of Medicinal Chemistry2014 57 (7), 2832-2842

    Among carbon, hydrogen, oxygen, and nitrogen, sulfur and fluorine are both leading constituents of the pharmaceuticals that comprise our medicinal history. In efforts to stimulate the minds of both the general public and expert scientist, statistics were ...

Cyril Portmann, Simon Sieber, Silvan Wirthensohn, Judith F. Blom, Laeticia Da Silva, Emilie Baudat, Marcel Kaiser, Reto Brun, and Karl Gademann

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An anecdotal response

by invivoVibrio

I have worked in several labs that have produced, either directly or through a spin-off company, real products that are medically useful. Scientists are the ones who create vaccines, design diagnostic devices and tests, and discover useful drugs.
There's a whole spectrum that falls under the title "science," which ranges from the purely discovery-oriented, focusing on just learning more about a topic for learning's sake; to the purely practical, such as so-called translational research, where scientists iron out the details of a practically useful discovery and optimize it for practical applications, "translating" the basic science into something that can be produced and sold by industry

Springer Structure-based Drug Discovery
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Cancer-Fighting Patch to Treat Mouth Cancer  — Drug Discovery & Development
Ohio State, through the Ohio State Innovation Foundation and the university's Drug Development Institute, and the University of Michigan licensed the intellectual property to the newly formed Sirona Therapeutics.

Springer Fragment-Based Drug Discovery and X-Ray Crystallography (Topics in Current Chemistry, Vol. 317)
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Royal Society of Chemistry Structure-Based Drug Discovery: An Overview (RSC Biomolecular Sciences)
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American Chemical Society Library Design, Search Methods, and Applications of Fragment-Based Drug Design (Acs Symposium Series)
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Academic Press Structural and Mechanistic Enzymology:, Volume 87: Bringing Together Experiments and Computing (Advances in Protein Chemistry)
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