Bioinformatics tools in drug Discovery // Drug Repurposing

Bioinformatics tools in drug Discovery

Professor Sir Tom Blundell
Professor Emeritus and Director of Research
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
tlb20[AT]cam.ac.uk
Details of OSDD Project(s):

An Open Source Integrated Computational Resource for the Analysis of the Structural Interactome to predict Off-Site Interactions of Drug Candidates 1.To maintain publicly accessible protein-structure interaction databases and tools at Cambridge and Bangalore 2.To make the databases and tools accessible as web services, whereby researchers can use them in conjunction with other public repositories. 3. To develop our databases that use homology to extend structural information in order to provide descriptors of protein-small-molecule, protein-protein and protein-nucleic acid in humans and in Mycobacterium tuberculosis, and between host and parasite. 4.Debasis Dash To develop databases of ‘pocketomes’ and of ‘interactophores’ that contain binding-site signatures of protein molecules from human and Mycobacterium tuberculosis proteins 5. To devise approaches to compare three-dimensional binding sites in different proteins and to identify off-target drug binding.

Short Bio-Data:

Tom researches on molecular and structural biology of growth factors, receptor activation, signal transduction and DNA repair, important in cancer and other diseases. He has published over 500 research papers, including 30 in Nature. He has written extensive software for structural bioinformatics and developed new approaches to structure-guided fragment-based drug discovery. In 1999 he co-founded Astex Therapeutics, an oncology company that is now public with eight drugs in clinical trials.Know More

Debasis Dash
Principal Scientist
CSIR-IGIB
ddash[AT]igib.res.in

Details of OSDD Project(s):

Broad Area of Research: Bioinformatics


N. Srinivasan
Professor
Molecular Biophysics Unit, Indian Institute of Science
ns[AT]mbu.iisc.ernet.in
Details...

You might also like

Drug Discovery & Development: Customization
Drug Discovery & Development: Customization
Drug Discovery in the sandbox
Drug Discovery in the sandbox

Writing is your drug of choice (bravo)

by nonicname

On the humanists' side of the Alp, one powerful idea has been the development of X-Bar theory, with its suggestion of a universal grammar at least for phrase structures. Steven Pinker has a superb exposition of the theory in The Language Instinct, and that is what I am adapting here (Pinker, S., The language instinct, 1994, pp. 74-152).
Consider a noun phrase about Hillary Rodham Clinton, the senator from New York from Arkansas The grammatical structure of the phrase consists of a header, "senator," which provides the organization for the rest of the phrase. The header "senator" takes an argument, a property that goes with it: being a senator includes being a senator representing some particular state, hence the senator from New York, header plus argument

AuthorHouse My Kid is Doing Drugs and Got Arrested: Now What?: A Guide for Parents and Others Who Love a Teenage Drug User
Book (AuthorHouse)

Cancer-Fighting Patch to Treat Mouth Cancer  — Drug Discovery & Development
Ohio State, through the Ohio State Innovation Foundation and the university's Drug Development Institute, and the University of Michigan licensed the intellectual property to the newly formed Sirona Therapeutics.

PSPG Publishing New Drugs: An Insider's Guide to the FDA's New Drug Approval Process for Scientists, Investors and Patients
Book (PSPG Publishing)
  • ISBN13: 9781419699610
  • Condition: New
  • Notes: BRAND NEW FROM PUBLISHER! 100% Satisfaction Guarantee. Tracking provided on most orders. Buy with Confidence! Millions of books sold!
Amazing Life Press Achieve Anything in Just One Year: Be Inspired Daily to Live Your Dreams and Accomplish Your Goals
Book (Amazing Life Press)
  • Used Book in Good Condition
What is One Solution? One Solution is three companies coming together to support your product development.(Givaudan, Roche Vitamins Inc., and Tetra ... An article from: Nutraceuticals World
Book (Rodman Publications, Inc.)
Little Brown & Co (P) Licit and Illicit Drugs; The Consumers Union Report on Narcotics, Stimulants, Depressants, Inhalants, Hallucinogens, and Marijuana - Including Caffei
Book (Little Brown & Co (P))