Bioinformatics tools in drug Discovery
Professor Emeritus and Director of Research
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK
Details of OSDD Project(s):
An Open Source Integrated Computational Resource for the Analysis of the Structural Interactome to predict Off-Site Interactions of Drug Candidates 1.To maintain publicly accessible protein-structure interaction databases and tools at Cambridge and Bangalore 2.To make the databases and tools accessible as web services, whereby researchers can use them in conjunction with other public repositories. 3. To develop our databases that use homology to extend structural information in order to provide descriptors of protein-small-molecule, protein-protein and protein-nucleic acid in humans and in Mycobacterium tuberculosis, and between host and parasite. 4. To develop databases of â€˜pocketomesâ€™ and of â€˜interactophoresâ€™ that contain binding-site signatures of protein molecules from human and Mycobacterium tuberculosis proteins 5. To devise approaches to compare three-dimensional binding sites in different proteins and to identify off-target drug binding.
Tom researches on molecular and structural biology of growth factors, receptor activation, signal transduction and DNA repair, important in cancer and other diseases. He has published over 500 research papers, including 30 in Nature. He has written extensive software for structural bioinformatics and developed new approaches to structure-guided fragment-based drug discovery. In 1999 he co-founded Astex Therapeutics, an oncology company that is now public with eight drugs in clinical trials.Know More
Details of OSDD Project(s):
Broad Area of Research: Bioinformatics
Molecular Biophysics Unit, Indian Institute of Science
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