Principles of Clinical Pharmacology // Drug Repurposing

Principles of Clinical Pharmacology

Five years have passed since the first edition of Principles of Clinical Pharmacology was published. The second edition remains focused on the principles underlying the clinical use and contemporary development of pharmaceuticals. However, recent advances in the areas of pharmacogenetics, membrane transport, and biotechnology and in our understanding of the pathways of drug metabolism, mechanisms of enzyme induction, and adverse drug reactions have warranted the preparation of this new edition.

PRINCIPLES OF CLINICAL PHARMACOLOGY by J. Atkinson Jr Second edition pdf free download

We are indebted to the authors from the first edition who have worked to update their chapters, but are sad to report that Mary Berg, author of the chapter on Pharmacological Differences between Men and Women, died on October 1, 2004. She was an esteemed colleague and effective advocate for studying sex differences in pharmacokinetics and pharmacodynamics. Fortunately, new authors have stepped in to prepare new versions of some chapters and to strengthen others. As with the first edition, most of the authors are lecturers in the evening course that has been taught for the past eight years at the National Institutes of Health (NIH) Clinical Center1.






J. Atkinson Jr




Second edition


7.42 MB

We also acknowledge the help of Cepha Imaging Pvt. Ltd. in preparing the new artwork that appears in this edition. Special thanks are due Donna Shields, Coordinator for the ClinPRAT training program at NIH, who has provided invaluable administrative support for both the successful conduct of our evening course and the production of this book. Finally, we are indebted to Tari Broderick, Keri Witman, Renske van Dijk, and Carl M. Soares at Elsevier for their help in bringing this undertaking to fruition.

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