Clinical Pharmacology career // Drug Repurposing

Clinical Pharmacology career

Nigel Baber, Morris J Brown, and David Webb set out the pros and cons

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Clinical pharmacology or, more precisely, clinical pharmacology and therapeutics is a relatively young specialty concerned with the understanding of drug action in man, and with the practice of rational prescribing.

Clinical pharmacology was born out of pharmacology - drug action in animals and in in vitro systems and out of the explosion in the number of new drugs which were emerging about 20 years ago.

Three developments

Three developments in particular have enabled the specialty to flourish and a fourth is responsible for current excitement.

Firstly, the recognition that clinical studies must be properly designed, executed, and analysed in order to be certain that observed drug effects are real and not due to chance, bias, or a placebo effect. In particular, the randomised, placebo controlled, or positive controlled double blind trial of sufficient size and power has been a mainstay of clinical pharmacology.

Secondly, the development of sensitive and specific assays of biological fluids by chromatography, and more recently by mass spectrometry, has enabled the detection of small quantities of parent drug and metabolises to be determined. This has enabled the subspecialty of pharmacokinetics - the study of the absorption, distribution, metabolism, and excretion of drugs to emerge.

Thirdly, the development of techniques to measure dynamic responses to drugs has allowed clinical pharmacologists to better define the dose effect or response relationship and to understand the mechanism of action of many important drugs. Some drugs can be used as tools or probes to understand physiological and pathophysiological processes, even if the drug itself never becomes a prescription medicine.

New challenge

The fourth and most recent development is the interaction of molecular genetics and studies on the human genome with drug response and drug development. As we move into the era where every gene and, in theory, every drug target is known, there is a challenge to, and demand for, clinical pharmacologists who are able to marry up disease with the right genes and drugs.

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Change in major/career this far into it?

by Leprechaun58

I find myself in a highly confusing state of affairs at present. Anyone with any college experience ought to be able to sympathize with what I'm going through... any advise would be most helpful.
I spent seven quarters in a BS in nursing program, going through the various rotations... during my second to last quarter, a stupid oversight on a patient case study (failure to cite a source) resulted in my having to withdraw from the clinical course and wait until the present quarter (winter) to re-do the rotation @ Swedish hospital. Up until that point, my GPA was 3.5... worked hard enough and did well enough to get into an exclusive internship and signed a contract to work at a Seattle Hospital come licensure

Wiley-Blackwell Medical Pharmacology at a Glance
Book (Wiley-Blackwell)
  • Used Book in Good Condition

Pharmacist Provider Status  — Pharmacy Times
In 2000, North Carolina was able to pass legislation that created a clinical pharmacist practitioner (CPP). We were able to work with the medical director for Medicare's Fiscal Intermediate to allow a CPP to bill for medical care as a provider.