Clinical and Experimental Pharmacology // Drug Repurposing

Clinical and Experimental Pharmacology

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Director, Clinical Pharmacology Experimental Therapeutics-CLI002981


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The Clinical Pharmacology and Experimental Therapeutics (CPET) department is composed of translational scientists responsible for bringing novel potential medicines into humans. We incorporate knowledge from laboratory and preclinical studies to define drug action in humans and prioritize development of the compounds with the greatest chance of success. Once a drug achieves proof of concept, CPET applies pharmacological principles to inform practitioners how to appropriately dose new medicines in different populations and in different clinical situations. We work in all the therapeutic areas in which Merck develops drugs including Cardiovascular Disease, Diabetes & Endocrinology, Immunology, Inflammation & Respiratory Disease, Infectious Disease, and Neuroscience. We believe physician-scientists are optimally positioned to participate in these stages of drug development.

A team approach is used at Merck to coherently and efficiently develop new drugs. Teams consists of experts in preclinical research, pharmacokinetics and drug metabolism, medicinal chemistry, pharmaceutical sciences, clinical sciences, biostatistics, modeling and simulation, regulatory strategy, program management, clinical trial operations and commercial development.

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by tlbrink

Clinical is probably the most useful. The skill set is transferable. My background was clinical and then I made the transition to industrial.
However, it is harder to go in the other direction, say from experimental to clinical. You can sail through those methods and stats classes, but you still have a lot of psychometry, psychopathology and pharmacology to go through in addition to the therapy.

Here are some of the articles used

by vizsladobengal

For the info I posted
•Bourreau, J., D. Hernot, et al. (2004). “Gastric emptying rate is inversely related to body weight in dog breeds of different sizes.” Journal of Nutrition 134: 2039S-2041S.
•Case, L., D. Carey, et al. (2000). Canine and Feline Nutrition: a resource for companion animal professionals. St. Louis, MO, Mosby, Inc.
•Ehrlein, H.-J. and J. Prove (1982). “Effect of viscosity of test meals on gastric emptying.” The Physiological Society.
•Hand, M. S., C. D. Thatcher, et al., Eds. (2000). Small Animal Clinical Nutrition. Topeka, KS, Mark Morris Institute

McGraw-Hill Medical Basic and Clinical Pharmacology 12/E (LANGE Basic Science)
Book (McGraw-Hill Medical)

People's Pharmacy: Nicotine gum could slow recovery from hip fracture  — Buffalo News
Regular use of a nonsteroidal anti-inflammatory drug (NSAID) like ibuprofen can increase the possibility of a heart attack (Basic and Clinical Pharmacology and Toxicology online, April 25, 2014) and counteract the heart-healthy effects of low-dose ..

McGraw-Hill Medical Basic & Clinical Pharmacology
eBooks (McGraw-Hill Medical)
Lange Medical Books Basic & Clinical Pharmacology, Ninth Edition
Book (Lange Medical Books)
McGraw-Hill Medical Katzung & Trevor's Pharmacology Examination and Board Review, Ninth Edition (McGraw-Hill Specialty Board Review)
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McGraw-Hill/Appleton & Lange Katzung's Pharmacology: Examination and Board Review
Book (McGraw-Hill/Appleton & Lange)