Autoimmune treatment // Drug Repurposing

Autoimmune treatment

Autoimmune Treatment

An international team, composed of 11 institutions from six countries, including BGI, presented the whole-genome sequence of Trichuris suis, a parasitic worm in pig. Understanding the genetics mechanisms underlying the pig parasite may aid to modify the human immune response that could result in better treatments for autoimmune diseases, including inflammatory bowel disease (IBD) and multiple sclerosis. The latest research was published online in Nature Genetics.

The human whipworm (Trichuris) infects around 1 billion people worldwide and causes a disease (trichuriasis) that results in major socioeconomic loses. In contrast, the pig whipworm causes disease and losses in livestock, but it does not cause disease in humans. It's reported that pig whipworm infection could even prevent inflammatory disease in humans, and has been used to treat inflammatory bowel disease and multiple sclerosis.

In this study, researchers sequenced the genomes of single adult female and male pig whipworm at about 140-fold coverage, producing draft assemblies of 76 Mb and 81 Mb, respectively. It was previously reported that the XX and XY karyotypes for female and male whipworm, respectively, but in this study researchers found no evidence for a Y chromosome among the male-specific scaffolds, suggesting that the sex chromosomes were the smallest chromosomal pair and were morphologically very similar in both sexes.

Intriguingly, they found the microRNAs (miRNAs) seem to have a major role in regulating sexual development in this species. Among them, the tsu-miR-228 in male, and tsu-miR-236 and tsu-miR-252 in female worms were predicted to regulate and suppress key feminizing and masculinizing developmental genes, respectively. According to the authors, this is the first time they observed such results in a metazoan.

When investigating how pig whipworm regulates the host immune response, researchers explored the stage-, sex- and tissue-specific transcription of mRNAs and small noncoding RNAs. The secretory proteins showed high representation in transcriptome of pig whipworm. The peptidases, particularly the secreted peptidases upregulated during larval development and in the stichosome, seemed to have a central role in human autoimmune disorders, primarily through inhibiting inflammation. Researchers also constructed the models of inflammatory bowel disease and other autoimmune disorders, trying to figure out a way for parasite-derived therapies.

Li Hu, Project Manager from BGI, said, "The constructed pig whipworm genome sequence provides us a genetic resource for deeply investigating the mechanisms underlying human autoimmune diseases. Meanwhile, the pig whipworm-host interactions will shed new light on the control of helminth and other immunopathological diseases in human. "

Explore further: Parasitic worms of pigs could provide new treatments of human diseases

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Anemia/thrombocytopenia treatment in dog

by MedWriter

About 3 weeks ago my 90-lb mixed breed dog was diagnosed with autoimmune anemia and thrombocytopenia (low platelets). His vet started him on high-dose prednisone and antibiotics for prevention. His blood counts have responded well. Vet also eliminated various pathogens as the cause. Here’s my concern: He now seems even more lethargic and weak than he did before starting treatment: couldn’t make it up the stairs this morning; barely wants to walk to the end of the block. Appetite is very good. I know that prednisone can lead to weakness/fatigue, but I’m concerned that his unusual lethargy may be more than should be expected

Recommend vet for autoimmune disease?

by louies_mom

Hello to all,
I have a dog who I believe has autoimmune problems of some sort, possibly SLE (systemic lupus). He has also recently had pancreatitis which complicates his treatment options, since he can't have cortisone.
He's being seen by a dermatologist who is running some tests this week, and he has a regular vet as well, who has started him on treatment.
The two vets are offering conflicting advice, and from my own research I am not convinced that either of them is very knowledgeable about autoimmune disorders, so I am starting to think that we need to see ONE vet who is familiar with these kinds of problems, that I can place my full trust and confidence in

Viral initiated autoimmune diseases? Any current

by PhageDude

Correlations?
I know there is an ever so slight link between Staph infections initiating Bechet's Disease (a horrible autoimmune disorder which I would not wish upon anyone).
It wouldn't surprise me at all to see a viral link.
Then we just have to find a cure, or at least a treatment that doesn't involve chemotherapy agents that make your hair fall out or sleep for two days straight.....

Addison's is an autoimmune disease

by just_browsing

So there's probably some relationship between that and allergies. Not to say that all AD dogs will have allergies but the likelihood would be higher.
"goofy" isn't an AD trait but dog's reaction to treatment/stress will alter some behavior. My dog is more energetic, more insane the day after I give her a shot. She feels fantastic. At the end of her cycle, when her electrolytes are dropping, she feels a little off and is more reserved. And since she's on pred, she's wired just a little tighter than she used to be.

Update: Autoimmune disease, attacking spinal

by 5150PRN

Cord and brain.
I posted last week about my dogs diagnosis and treatment. I picked her up last Wednesday from Davis. Today, a week later she's doing MUCH better. Almost her old self. It was gradual, I could see slight improvement everyday. Hopefully she'll keep improving and stay healthy.
later you guys!

The genes behind immunity  — Science Codex
Other articles examine crucial applied questions, such as how genes influence autoimmune thyroid diseases, or which chickens are the most resistant to colonization by Campylobacter jejuni, one of the most common causes of food-borne illness in humans.

BookSurge Publishing The Treatment of Auto-Immune Diseases
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