Autoimmune disease lupus // Drug Repurposing

Autoimmune disease lupus

e-mail-overload2I have had MANY emails from people asking me quite technical questions regarding HSCT, side effects, and risks. I advise everyone who has been accepted for treatment to consult with a local haematologist so that they may discuss the chemotherapy protocol with an independent professional, and so that they can schedule appointments with the haematologist starting from around a week after they return to Australia. My haematologist is fabulous. He was very supportive of my treatment. I saw him one week after I returned to Australia, and then weekly (with blood tests) for a total of two months, before it became fortnightly and then monthly. Now, nearly 8 months after transplant, I see him every eight weeks so he can review current blood test results.

One of the common questions I get relates to secondary autoimmune diseases. As a disclaimer, you should know I can’t legally advise you in a medical capacity. I am not a doctor, and I cannot give nursing advice outside of my scope of practice (I am not a haematology, immunology or neurology nurse). Below is some information regarding secondary autoimmune diseases – all of which can be sourced by reviewing scholarly publications online:

The European Bone Marrow Transplant Group conducted a study of patients with autoimmune diseases who had autologous HSCT between 1995-2009 and found that out of 347 patients, 29 developed a secondary autoimmune disease within 21 months of HSCT (Daileler et al., 2011). That is just over 8%. This number does not differentiate between patients who had myeloablative and non-myeloablative regimes. The secondary autoimmune diseases ranged from graves disease, to thyroiditis, acquired hemophilia, psoriasis, and rheumatoid arthritis, among others. With all due respect to people with these diseases, they all sound a lot better than MS in my opinion. Some people may disagree. After 5 years, the risk of acquiring a second autoimmune disease was around 9.8%. Significant risk factors for acquiring the second autoimmune disease were a young age at time of HSCT, the use of ATG (Dr Fedorenko does not use ATG; he prefers Rituximab) and Lupus as the first autoimmune disease (Daileler et al., 2011; Loh et al., 2007; Daileler et al., 2012).


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Rheumatoid arthritis can be accompanied by another autoimmune disease called Sjogren's syndrome. Among other nasty things, it causes severe dry eyes, mouth, vag.
Sjogren's can occur on it's own, but is far more likely to accompany lupus or RA. If she doesn't have those, it is unlikely she has Sjogren's.
I had a big issue with dryness during pregnancy.
Bleeding during sex and severe bleeding during periods is something she should take up with her doctor. Good thing she's having regular visits with her ob/gyn.

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