Autoimmune disease and pregnancy Thyroid // Drug Repurposing

Autoimmune disease and pregnancy Thyroid

Pregnancy And Thyroid DisordersOne of the main causes of hypothyroidism during pregnancy is Hashimoto’s thyroiditis. This is an autoimmune disorder in which the immune system attacks the thyroid gland thus leading to an under active thyroid and low production of hormones.

Patients suffering from this disease show symptoms such as tiredness, irritation, puffiness in face, dry skin, fatigue, sensitivity to cold, weight gain. If a woman already suffers from this condition then she might get hypothyroidism during pregnancy. Inadequate treatment for the hypothyroidism or over treatment can also lead this condition.

Hypothyroidism during pregnancy poses risks not only for the mother but also for the unborn baby. Untreated hypothyroidism can result in muscle pain and weakness along with placental abnormalities, congestive heart failure and anemia in the mother. The condition can be risky for the child as well as the thyroid hormone is essential for the development of the brain in the baby. In the first twelve weeks of the gestation period a baby relies completely on the mother for thyroid hormone as its own gland is still undeveloped.

Absence of thyroid hormone during this stage can lead to the child being born with impaired brain development and other neurological and developmental abnormalities. Hypothyroidism also poses the risk of the woman developing preeclampsia and low birth weight in babies. To avoid these complications a pregnant woman’s TSH levels should be checked once the pregnancy is confirmed. This is especially important for those women with previous cases of hypothyroidism or those who have a family history of this condition.

If hypothyroidism is detected then the doctor may have to control the TSH levels with appropriate medications which include levothyroxine doses along with regular check ups.

Hyperthyroidism During Pregnancy

Another thyroid disorder during pregnancy is hyperthyroidism which is characterized by the over production of the thyroid hormone due to an overactive gland. Maternal hyperthyroidism is often caused by the Graves disease.

This is an autoimmune disorder which causes the release of antibodies that lead to the stimulation of the thyroid gland and the production of TSI. The woman suffering from this condition can suffer from severe morning sickness or suffer from preeclampsia in certain extreme cases. When left untreated, hyperthyroidism can lead to premature or still births, congenital malfunctions, premature births, low birth weight and fast heart rate in babies. Treatment with anti thyroid drugs such as Methimazole can help in controlling maternal hyperthyroidism.

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Http://www.thyroid.ca/Articles/EngE11B.html

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Clinical and Laboratory Features
The most common symptoms of post-partum hyperthyroidism occurring 6-12 weeks after delivery were fatigue, increased sweating, palpitations, and perhaps nervousness and weight loss; and subsequently, common symptoms occurring 12-24 weeks post-partum included fatigue, weight gain, lethargy and depression in the hypothyroid phase. Some of the risk factors observed in predisposing individuals to post-partum hypothyroidism are a previous episode (either related or unrelated to pregnancy), a positive family history of autoimmune thyroid disease, non-thyroidal autoimmune diseases in first degree relatives, and previous episodes of Graves' disease or post-partum Graves' disease, and previous active thyroid disease and autoimmunity, with positive antithyroid antibody tests

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by Werdna

From the article
"elevated levels of a substance called Lp(a) do provide an accurate marker for proneness to heart disease. In a recent study, consumption of soy was shown to raise levels of Lp(a).39"
"A 1990 study documents the association of soy formula feeding in infancy and autoimmune thyroid problems.20 A 1991 study in Japan found that soy consumption can suppress thyroid function and cause goiters in healthy people, especially elderly subjects.29 In rats, excess soybean intake with iodine deficiency caused abnormal growth of the thyroid gland.27"
"Another study found that twice as many soy-fed children developed diabetes as those in a control group that was breast fed or received milk-based formula

Endocrine Society Clinical Approach to Endocrine and Metabolic Diseases
Book (Endocrine Society)

Erie race will benefit 2 with health issues  — Toledo Blade
Zoie has an autoimmune deficiency and receives monthly life-saving treatment at Mercy St. Vincent Medical Center.